![]() ![]() Phytoestrogens work to maintain a certain amount of hormonal activity. In estrogen deficit, DIM increases estrogen activity. The lack of effect may possibly be due to the need for the other glucosinolates compounds and the cofactors methylated folate and vitamin B12, which are necessary for this pathway. The research on DIM for this purpose is not adequate, with small groups and short durations, and is far from convincing. Very low doses of DIM (less than 100mg daily) in combination with other sulforaphane's and necessary cofactors folate and B12 as found in nature can help alter estrogen detoxification pathways in the gut and liver and improve the 2:16 alpha hydroxyl estrone ratios to reduce excessive estrogen activity. DIM was found to be more stable and more suitable for use in supplements. Indole-3-carbinol was studied extensively and found to be effective and beneficial for cancers but was shown to be very unstable. ![]() Broccoli also contains glucobrassicin, the glucosinolate precursor of indole-3-carbinol (I3C), and subsequently Diindolylmethane (DIM). Glucoraphanin is a stable plant glucosinolate that is converted to the active isothiocyanate, sulforaphane by an enzyme known as myrosinase. These foods contain a multitude of beneficial phytonutrients, activated vitamins, and cofactors in particular glucosinolates. The discovery of DIM stems from research on the anticancer potential of a diet high in cruciferous brassica vegetables such as broccoli, broccoli sprouts, radishes, pak Choy, kale, brussels sprouts and cabbages. Dim - Diindolylmethane is an anti-estrogen This is one of the ways DIM can help in cases of prostate cancer the other way is by inhibiting mTOR pathways that lead to cell growth and division but we will discuss mTOR in greater detail later when we discuss muscle hypertrophy. testosterone and dihydrotestosterone) receptors and inhibit the protein synthesis induced by the anabolic effects of androgens. Higher doses (greater than 100mg) of isolated pure DIM can saturate tissues and block androgen (e.g. This product is not intended to diagnose, treat, cure, or prevent any disease.Share on Facebook Tweet on Twitter Pin on Pinterest Email this page DIM - Diindolylmethane is an androgen antagonist!ĭIM blocks the effects of testosterone. ** The Food and Drug Administration has not evaluated these statements. Then you would not take the supplement for 1-2 months before considering using it again based on how you responded or any re-testing.įor further advice, consult a practitioner or an endocrinologist about your hormone levels and symptoms to determine the best course of action. The suggested dose is 1 capsule per day, and a cycle could be 1 capsule per day until the container is finished. USAGE AND GUIDELINESĭIM can significantly improve estrogen balance however, to ensure it is balanced and that you don’t reduce estrogen too far, it is a good idea to cycle this supplement. Managing estrogen can also benefit your liver since your liver is the body’s main detoxification site, and reducing the estrogen that your liver needs to remove will save some workload through this organ. DIM works by increasing 2-hydroxyestrone and improving the 2/16 hydroxyestrone ratio.** BENEFITSįor women, excess estrogen can lead to fibrocystic lumps in their breasts, irregular menstrual cycles, decreased sex drive, or weight gain.įor men, managing estrogen would be something to consider if you suffer from gynecomastia (development of male breast tissue), erectile dysfunction or lack of sex drive, infertility, or struggle to lose body fat.ĭIM can also limit the conversion of testosterone to estrogen, and maintaining testosterone levels would improve muscle gain, strength and athletic performance in the longer term. Research tells us that a low level of the 2-hydroxyestrone and a high level of 16 alphahydroxyestrone is not desired. ![]() This process uses a proprietary blend of MCT oils, non-soy derived lecithin, and vitamin E without potentially harmful surfactants. ![]() For this reason, DIM + has been manufactured utilising the proprietary Designs for Health Evail process, improving DIM’s absorption. DIM + provides 100 mg per softgel of diindolylmethane (DIM), a compound that supports healthy estrogen metabolism.** DIM absorption is minimal when given orally due to its crystalline structure. ![]()
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